Buspirone - Interactions with other Active Compounds

Buspirone + Alprazolam

(Mutually) oppression CNS.

Buspirone + Buprenorphine

(Mutually) oppression CNS.

Buspirone + Valproic acid

Against the background of valproic acid is enhanced CNS depression.

Buspirone + Verapamil + Trandolapril

With simultaneous use of verapamil (consisting of a combination of trandolapril + verapamil) with buspirone increases AUC and Cmax of buspirone "by 3.4 times.

Buspirone + verapamil

With simultaneous use of buspirone and verapamil (inhibitor of CYP3A4) interaction is possible.

Buspirone + Haloperidol

Buspirone (mutually) oppression CNS. You can buy online Haloperidol.

Buspirone + hydroxyzine

Buspirone (mutually) effect; with a joint appointment the dose should be reduced by 50% - a high probability of severe, even fatal, complications.

Buspirone + guanfacine

(Mutually) sedation.

Buspirone + Diazepam

In a joint application of diazepam and buspirone nordiazepama level increases and may increase the risk of side effects: dizziness, headache, nausea.

Buspirone + Diazepam

Buspirone (mutually) effect; against the background of / in the introduction of diazepam increases CNS depression and an increased risk of apnea.

Buspirone + Digoxin

With simultaneous use of buspirone (strongly - 95% - is bound to a protein) may displace from its association with digoxin serum proteins.

Buspirone + Diltiazem

With simultaneous use of buspirone and diltiazem (an inhibitor of CYP3A4) interaction is possible.

Buspirone + diphenhydramine

(Mutually) oppression CNS, may increase the hypnotic effect.

Buspirone + Hypericum perforatum herb extract

In an application with buspirone may increase its action and the appearance of symptoms such as nausea, vomiting, fear, anxiety, confusion.

Buspirone + Itraconazole

With simultaneous use of itraconazole (an inhibitor of CYP3A4) increases the concentration in plasma buspirone.

Buspirone + Itraconazole

Against the background of itraconazole (blocks biotransformation) significantly increased plasma concentrations of buspirone.

Buspirone + Clonazepam

The potentiation of CNS depression.

Buspirone + Metoclopramide

(Mutually) sedation.

Buspirone + Moclobemide

Described increase in blood pressure and the occurrence of hypertensive crisis after the simultaneous application of buspirone and moclobemide (a reversible MAO inhibitor); in this regard can not be combined with buspirone with moclobemide. It will take at least 14 days after discontinuation of buspirone before the application moclobemide; However, buspirone may be administered on day 1 after the abolition of moclobemide.

Buspirone + Risperidone

When used together, care is needed.

Buspirone + Rifampicin

With simultaneous use of rifampicin (a strong inducer of CYP3A4) accelerate buspirone metabolism and can significantly reduce levels of buspirone in the blood plasma, and reduce its pharmacodynamic effects.

Buspirone + selegiline

Described increase in blood pressure and the occurrence of hypertensive crisis after the simultaneous application of buspirone and selegiline (irreversible MAO inhibitor); in this regard, buspirone can not be combined with selegiline. After the abolition of selegiline before the application of buspirone (and vice versa) should be at least 14 days.

Buspirone + Topiramate

(Mutually) oppression CNS.

Buspirone + Tramadol

(Mutually) oppression CNS; the combined appointment is necessary to reduce the dose.

Buspirone + cimetidine

In a joint application of cimetidine and buspirone buspirone Cmax increased by 40%, and its AUC does not change; joint application requires close medical supervision.

Buspirone + Erythromycin

With simultaneous use of erythromycin (an inhibitor of CYP3A4) increases the concentration in plasma buspirone.