GABA - Calm and Relax

GABA or gamma-aminobutyric acid has a worst enemy, ideological adversary main excitatory neurotransmitter - glutamate, which we mentioned earlier. Confrontation between the two does not seem to oppose predator and prey, probably a predator and predator, as the Cold War between the USSR and the US, taking place in our brain. Everyone has their own pros and cons, there is no good neurotransmitter, as there is no bad. Each advantageous is under certain circumstances.

How does GABA act?

1.GABA slows signaling in adult neurons, and stimulate the young, in the developing brain. It is a little known fact about which scientists are still arguing, telling us about a possible plasticity, flexibility, individual approach of this neurotransmitter.

2.Increases growth hormone. On this point there were many questions after the story about Phenibut. Let us dwell in more detail. 11 men aged 18-30 years received either 3 grams of GABA in the form of supplements or a placebo. Then they either practiced or rested. Changes were monitored by analysis of blood every 15 after administration.

Results: Within hours after ingestion occurred increasing the concentration of growth hormone in the 200-400%.

Another study says, and in parallel to the increase of prolactin in some people, in addition to growth hormone.

3.GABA increases brain glucose utilization and improves the blood circulation of the brain tissue. These parameters can be included in the concept of "healthy brain." Poor circulation - it is a problem of the modern society, gamma-aminobutyric acid partly solves this problem. Just consider the huge number in mind will not succeed, "brain configuration" will also be in order.

4. It promotes better falling asleep and having nootropic and anti-convulsive effect. GABA from the '60s is used in medicine and these effects for years checked / rechecked.

GABA receptors

Currently, biology allocate only 2 types of receptors: GABA A and GABA B in the Russian-language Wikipedia was not even Type 3 - As of GABA C previously thought, because they were refractory to the GABA receptors of benzodiazepines and barbiturates (classes of antidepressant and sedatives), and once impervious - so it will be a GABA C receptors are now still referred to as GABA A.

GABA A

The receptors on the surface of nerve cells, which interact with the GABA neurotransmitter molecules. Ie one molecule, but it may accede to the two receptor types. The first - a GABA A.

The ionotropic receptors, such as ionotropic glutamate receptors. The action of the opposite. Recall that the ionotropic receptors are included in the job just a millisecond, when the frequency of such pulses. GABA acts as a receptor for this, he begins to share trace elements, one out of the neuron, others go. The result - a change potential, in this case - pulse suppression. Thus, the rate of exchange of information between nervous cells is reduced. On the one hand, it is bad for the man, "slower" thinking, on the other - reduces the likelihood of errors.

GABA has a sedative, hypnotic, euphoric action. By the way, amanita produce muscimol, the psychoactive component of working with the GABA receptor A. You can buy Picamilon.

There is one more interesting stuff, nootropic effect - xenon. Probably, many people know that there are xenon lamps, lights in the car, but there are xenon therapy (a mixture of xenon and oxygen), which activates these receptors and is actively used in sports to highlight the body of erythropoietin, and this is a major doping of athletes, which is important endurance. It was a small digression)

GABA B

The second type of today's neurotransmitter and receptor is a metabotropic substance. If ionotropic worked quickly and often, the metabotropic does not change the potential of the cell and interacts with certain proteins inside the cell called G-proteins. There is a complex biochemical process, the outcome of which becomes a change of the nerve impulse. GABA B has a long, fade effect.

This receptor is activated by many drugs, even stimulating. Its lack of activation leads to schizophrenia and depression. It weakens adenyl cyclase simplistically be less energy and can to some extent be analgesic.

Pros of GABA

+ Calmness and confidence. You do not care more urgent cases, they seem distant and unimportant.

+ Good mood. It helps to cope with stress and mild depression.

+ Healthy brain. Good blood circulation and delivery of glucose - the energy.

+ Attention / high efficiency of intelligence. When you are calm, you find it easier to concentrate on certain things and not get distracted by everything around.

GABA Cons:

- It is hard to think quickly. Ambient believe brake.

- Don’t-careless sometimes unhealthy.

- It is difficult to switch from one case to another. Inertia. Not suitable for "the number", when there is little time.

Increase GABA naturally: yoga, meditation, sleep, rest.

Supplements and Drugs that increase GABA:

- Vitamin B6 converts glutamate into GABA.

- St. John's Wort / Hyperforin (GABA reuptake inhibitor)

- valproic acid, Melissa (GABA transaminase inhibitor, destruction of the neurotransmitter)

- Barbiturates, Benzodiazepines (agonists GABA A)

- Phenibut, Picamilon, GHB (agonists GABA B)

- Alcohol. Uniquely acts on GABA receptors, is not known exactly what data is separated.

- Theanine.

Supplements that reduce GABA:

- Phenylethylamine (antagonist of GABA B + stimulant)

There lots of supplements – the main aim is push to norepinephrine and glutamate. The more - the less GABA, a negative feedback mechanism.

Bottom line:

- Gamma-aminobutyric acid is responsible for the peace and tranquility.

- This acid has the exact opposite of glutamate, although they are both of the glutamic acid.

- Glutamate, they are a negative feedback mechanism. When one substance more - another immediately becomes smaller.

The substance is extremely useful and extremely harmful, depending on the timing of the reception, the goals and dosages. Often remember it! Good luck!