Adamantyl bromophenylamine- trade name Ladasten

A drug, a psychostimulant, an anxiolytic, an immunotropic drug.

Pharmachologic effect

- Enhanced synthesis and Ca2 + -dependent processes of dopamine release. The ability of the drug to enhance the synthesis of dopamine de novo fundamentally differentiates the drug from typical psychostimulants. Due to the increased synthesis of dopamine, with the treatment with adamantyl bromophenylamine there is no depletion of the neuronal reserves of catecholamines.

- Restoration of stress-depleted GABA-receptors and a decrease in the expression of the gene encoding the GABA GAT-3 carrier protein synthesis. GAT-3 is one of the isoforms of the GABA transfer protein, which reuptakes GABA from the synaptic cleft. By reducing the expression of the gene that codes for the synthesis of this protein, the GABA content in the synaptic cleft is increased, which increases the GABA-transmission and is a factor in increasing the binding of the ligands to the GABA-benzodiazepine-chloronophore complex.

- Antiradical action: reduces the activity of excessively elevated processes of lipid peroxidation, contributes to the preservation of the integrity and barrier function of cellular and mitochondrial membranes.

Indications

Asthenic conditions of various genesis, including somatic diseases and after the transferred infectious diseases.

Neurasthenia.

From the side of the central nervous system: there can be signs of excessive activation and a disorder of falling asleep.

From the cardiovascular system: development or aggravation of heart failure, orthostatic hypotension; hypertension, rarely - arrhythmia, tachycardia.

Other: allergic reactions (with increased individual sensitivity to the drug).

Adamantyl bromophenylamine belongs to the group of so-called actoprotectors - drugs of different groups, which increase the body's defenses. Adamantibromphenylamine was developed by Soviet military physicians as a means of increasing overall immunity, endurance of a person. It was found that the drug also has a psychostimulating effect. In addition, he disguises the use of steroids: all standard doping procedures that the IOC practiced turned out to be ineffective against adamantyl bromophenylamine.