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Duoprost eye drops 2.5ml

USD 35.99

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Duoprost eye drops - is a combined antiglaucomatous agent for topical application, capable of reducing intraocular pressure by activating the outflow of watery eyes. Has antiglaucomatous effect.

Antiglaucoma combined preparation.

Latanoprost is an analogue of prostaglandin F2α and a selective agonist of FP receptors. Reduces intraocular pressure by increasing the outflow of aqueous humor and has anti-glaucoma effect. The main mechanism of action of latanoprost is associated with an increase in uveoscleral outflow. Does not have a significant effect on the production of aqueous humor and does not affect the hemato-ophthalmic barrier.

Timolol is a non-selective blocker of β-adrenergic receptors with a slight internal sympathomimetic and membrane-stabilizing activity. With topical application lowers the intraocular pressure by reducing the formation of watery moisture and a small increase in its outflow.

Pharmacokinetics

Latanoprost

Suction and distribution

Cmax in aqueous humor (approximately 15-30 ng / ml) is achieved 2 hours after instillation into the eye. After the application of eye drops, latanoprost is distributed, first of all, in the anterior segment of the eye, in the conjunctiva and in the eyelids. Only a small amount of the drug reaches the posterior segment. Latanoprost undergoes hydrolysis in the cornea under the action of esterases to form a biologically active acid.

Metabolism and excretion

Metabolism of latanoprost acid in the tissues of the eye practically does not occur. The main metabolism occurs in the liver. T1 / 2 from the plasma is 17 minutes. The main metabolites, 1,2-dinor- and 1,2,3,4-tetranor metabolites, do not or have weak biological activity and are mainly excreted in the urine.

Timolol

With topical application timolol quickly penetrates through the cornea. After instillation of eye drops Cmax timolol in the aqueous humor of the eye is achieved after 1 hour.

T1 / 2 from the plasma - 6 hours. It enters the systemic bloodstream in an insignificant amount by the absorption through the vessels of the conjunctiva, the nasal mucosa and the lacrimal tract. The excretion of timolol metabolites is mainly carried out by the kidneys.

Indications:

  • open-angle glaucoma;
  • increased intraocular pressure.

Contraindications:

  • A bronchial asthma or a history of bronchial asthma, chronic obstructive pulmonary disease;
  • sinus bradycardia;
  • AV-blockade II-III degree;
  • decompensated chronic heart failure of II-III degree;
  • cardiogenic shock;
  • age to 18 years;
  • the period of breastfeeding;
  • hypersensitivity to the components of the drug.

Carefully

Inflammatory, neovascular, zakratougolnaya or congenital glaucoma, open-angle glaucoma in combination with pseudophakia, pigmentary glaucoma (due to lack of sufficient experience of the drug); aphakia, pseudo-aphakia with a rupture of the posterior capsule of the lens, patients with risk factors for macular edema (in the treatment with latanoprost, cases of development of macular edema, including cystoid) are described.

Special instructions:

The drug can cause a gradual change in eye color by increasing the amount of brown pigment in the iris, periodic monitoring of the treating physician is recommended.

The drug contains a preservative of benzalkonium chloride, which can be absorbed by contact lenses and have a damaging effect on the eye tissue. Therefore, it is necessary to remove contact lenses and re-install them 15 minutes after instillation.

Impact on the ability to drive vehicles and manage mechanisms

Burying eye drops can cause a transient sensation of "shroud before your eyes" for several minutes, which should be taken into account when driving a car and working with moving mechanisms. While this effect does not disappear, patients should not drive a car or use sophisticated technology.

Side effects:

  • Visual disturbances, blepharitis, cataract, conjunctivitis, conjunctival allergic reactions (follicles, pinpoint hemorrhages, papillary conjunctival reactions, etc.), corneal lesions (pigmentation, erosion, spot keratitis, etc.), refractive disorders, redness of the eye, pain, irritation eyes, increased pigmentation of the iris, keratitis, photophobia, loss of part of the fields of vision, decreased sensitivity of the cornea, ptosis, refraction change, diplopia.
  • Ischemia of the brain, circulatory disorders.
  • Diarrhea, indigestion, dry mouth, nausea, retroperitoneal fibrosis.
  • Shortness of breath, bronchospasm.
  • Infections of the upper respiratory tract, sinusitis, pr.
  • Diabetes mellitus, hypercholesterolemia.
  • Angioedema, anaphylaxis, urticaria, generalized rash.
  • Depression, headache, dizziness, confusion.
  • Increased blood pressure.
  • Hypertrichosis, skin irritation, rash, halachion, etc.
  • Arthritis, pain in the muscles, joints.
  • Intermittent claudication, Raynaud's syndrome, lowering blood pressure.
  • Impotence, Peyronie's disease.

Suggested Use:

Locally.

Bury 1 drop in the eye (a) 1 time / day. If one dose was missed, then in the future it is necessary to continue treatment, introducing the next dose as usual.

If a patient is assigned more than one preparation for topical administration for an ophthalmic disease, these drugs should be administered at intervals of not less than 5 minutes.

Packaging:

  • Comes in original packaging. Item is brand new and unopened.

Storage:

  • Keep away from direct sunlight.
  • Keep locked and away from children.
  • Store in dry place at room temperature.
  • Do not exceed storage temperature higher than 25 C

Important notice- the outer box design may vary before prior notice!

 

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