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Instructions

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Instruction for use: Trexyl

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Dosage form: tablets

Active substance: Terfenadine*

ATX

R06AX12 Terfenadine

Pharmacological group:

H1-Antihistamines

The nosological classification (ICD-10)

J06 Acute upper respiratory tract infections of multiple and unspecified locations: Frequent colds of viral diseases; Infections of ENT organs; Acute respiratory illness of influenza nature; Pain for colds; Acute catarrhal disease; Cold; Colds; Colds; Respiratory infection; Seasonal catarrhal disease; Seasonal colds; Pain in infectious and inflammatory diseases of the upper respiratory tract; Bacterial infections of the upper respiratory tract; Bacterial infections of the respiratory system; Viral respiratory disease; Viral respiratory tract infections; Inflammatory disease of the upper respiratory tract; Inflammatory diseases of the upper respiratory tract; Inflammatory diseases of the upper respiratory tract with difficult to separate sputum; Inflammatory respiratory disease; Secondary infections for colds; Difficult sputum separation in acute and chronic respiratory diseases; Upper respiratory tract infections; Infections of the upper respiratory tract; Respiratory tract infections; Respiratory and lung infections; Infectious-inflammatory diseases of the upper respiratory tract; Infectious-inflammatory diseases of the upper respiratory tract and ENT organs; Infectious-inflammatory diseases of the upper respiratory tract in adults and children; Infectious-inflammatory diseases of the upper respiratory tract; Infectious inflammation of the respiratory tract; Respiratory tract infection; Qatar upper respiratory tract; Catarrh of the upper respiratory tract; Catarrh of the upper respiratory tract; Catarrhal phenomena from the upper respiratory tract; Cough in diseases of the upper respiratory tract; Cough for colds; ARVI; ARI; ARI with phenomena of rhinitis; Acute respiratory infection; Acute infectious-inflammatory disease of the upper respiratory tract; Acute respiratory disease; Persecution in the throat or nose; Respiratory and viral infections; Respiratory diseases; Respiratory infections; Recurrent respiratory tract infections; Secondary infections with influenza; Influenza states; Feverish conditions for influenza

J30 Vasomotor and allergic rhinitis: Allergic rhinopathy; Allergic rhinosinusopathy; Allergic diseases of the upper respiratory tract; Allergic rhinitis; Allergic rhinitis seasonal; Vasomotor runny nose; Prolonged allergic rhinitis; All-year-round allergic rhinitis; All-year allergic rhinitis; Year-round or seasonal allergic rhinitis; All-the-year-round rhinitis of an allergic nature; Rhinitis vasomotor allergic; Exacerbation of pollinosis in the form of rhinoconjunctival syndrome; Acute allergic rhinitis; Edema of the nasal mucosa; Edema of the nasal mucosa; Edema of the mucous membrane of the nasal cavity; Swelling of the nasal mucosa; Swelling of the nasal mucosa; Pollinosis; Permanent allergic rhinitis; Rhinoconjunctivitis; Rhinosinusitis; Rhinosinusopathy; Seasonal allergic rhinitis; Seasonal allergic rhinitis; Hay rhinitis; Chronic allergic rhinitis; Allergic diseases of the respiratory tract

J45.0 Asthma with predominance of the allergic component: Asthma of bakers; Allergic lung diseases; Bronchial asthma, professional; Aspirin Asthma; Asthma atopic; Asthma bronchial atopic; Atopic asthma; Atopic bronchial asthma; Persistent atopic bronchial asthma; Allergic diseases of the respiratory tract

K52.2 Allergic and alimentary gastroenteritis and colitis: Alimentary colitis; Allergic Colitis; Gastroenteritis alimentary; Gastroenteritis allergic; Allergic diarrhea; Allergic gastroenteropathy; Medicinal gastroenteritis

L20 Atopic dermatitis: Allergic diseases of the skin; Allergic skin disease noninfectious etiology; Allergic skin disease etiology nemikrobnoy; Allergic skin diseases; Allergic skin lesions; Allergic reactions on the skin; atopic dermatitis; Allergic dermatosis; Allergic diathesis; Allergic itching dermatosis; Allergic skin disease; Allergic skin irritation; allergic Dermatitis; atopic Dermatitis; allergic dermatoses; exudative diathesis; Itchy atopic eczema Itchy allergic dermatosis; Allergic skin disease; Cutaneous allergic reaction to drugs and chemicals; Cutaneous reactions to medications; Skin and allergic disease; Acute eczema; common neurodermatitis; Chronic atopic dermatitis; Exudative diathesis

L29 Itching: Itching with partial obstruction of the biliary tract; Dermatitis itchy; Dermatosis with persistent itching; Other itching dermatoses; Itching dermatoses; Itching allergic dermatosis; Itching dermatitis; Itching dermatosis; Itching itch; Excruciating itching; Severe itching; Endogenous itching; Skin itching with dermatosis; Restricted itchy dermatitis; Itching of the skin; Itchy scalp; Itching eczema

L30.9 Unspecified Dermatitis: Allergic dermatoses complicated by a secondary bacterial infection; Anal eczema; Bacterial maturation; Varicose Eczema; Venous dermatitis; Inflammation of the skin; Inflammation of the skin upon contact with plants; Inflammatory Skin Disease; Inflammatory Skin Diseases; Inflammatory Skin Diseases; Inflammatory skin reactions; Inflammatory processes of the skin; Hypostatic dermatitis; Fungal Eczema; Fungal dermatosis; Dermatitis; Dermatitis is stagnant; Dermatitis and eczema in the anal area; Dermatitis acute contact; Perianal dermatitis; Dermatosis; Dermatosis of the scalp; Dermatosis of psoriasis; Dermatosis with persistent itching; Dermatoses; Dermatoses itchy; Other itching dermatoses; Significant eczematous manifestations; Itching with dermatoses; Itching eczema; Itching dermatoses; Itching dermatitis; Itching dermatosis; True eczema; Skin reaction to insect bites; Skin itching with dermatosis; Constitutional eczema; Weeping eczema; Drowsing inflammatory skin disease; Dying Infectious-Inflammatory Skin Disease; Non-allergic dermatitis; Nummular eczema; Acute contact eczema; Acute inflammatory skin disease; Acute dermatosis; Acute severe dermatosis; Perianal dermatitis; Superficial dermatosis; Subacute Contact Eczema; Simple dermatitis; Occupational dermatitis; Psychogenic dermatosis; Bubble dermatitis of newborns; Pustular eruptions; Irritation and redness of the skin; Low-flammable eczema; Dry atrophic eczema; Dry eczema; Toxic dermatitis; Ear eczema like dermatitis; Chronic eczema; Chronic dermatosis; Chronic dermatosis; Chronic common dermatosis; Scaly papular dermatosis; Eczema; Eczema anal region; Eczema of the hands; Eczema Contact; Eczema lichenized; Eczema Nummular; Eczema acute; Eczema acute contact; Eczema subacute; Eczematous dermatitis; Eczema-like rashes; Ecome exogenous; Endogenous eczema; Gluteal dermatitis; Limited itching dermatitis

L50 Urticaria: Idiopathic chronic urticarial; Injury Urticaria; Chronic urticarial; Hives of the newborn

L53 Other erythematous conditions: Variable erythrokeratodermia; Malignant exudative erythema; Erythema; Erythematous; Erythroderma; Erythema from diapers

T78.4 Unspecified Allergy: Allergic reactions to insulin; Allergic reactions to insect stings; Allergic reactions similar to systemic lupus erythematosus; Allergic diseases; Allergic diseases of mucous membranes; Allergic diseases and conditions resulting from increased release of histamine; Allergic diseases of mucous membranes; Allergic symptoms; Allergic symptoms in the mucous membranes; Allergic reactions; Allergic reactions caused by insect bites; Allergic reactions; Allergic conditions; Allergic laryngeal edema; allergopathy; allergic conditions; Allergy; House dust allergy; Anaphylaxis; Cutaneous reactions to medications; Skin reaction to insect stings; Cosmetic allergy; Drug allergy; Acute allergic reaction; Laryngeal edema allergic genesis and background radiation; Food and drug allergy

Composition and release form

1 tablet contains terfenadine 60 mg; In the blister 10 pcs., In the box 1 or 10 blisters.

Pharmachologic effect

Mode of action - anti-allergic, antihistamine.

It blocks histamine H1 receptors.

Pharmacodynamics

The frequency of sedation (drowsiness, weakness, dizziness, impaired concentration) is similar to that with placebo and 2 times lower than with traditional antihistamines.

Pharmacokinetics

Well absorbed from the digestive tract; Binding to plasma proteins - 97%; Most of it is converted into active metabolites in the liver. After ingestion (60 mg), the maximum concentration in the plasma of terfenadine is reached after 1 hour, active metabolites - after 2-3 hours. The half-distribution period is 3-4 hours, the half-life is 16-23 hours (an average of 17 hours). The action begins in 1-2 hours, reaches a maximum after 3-4 hours and lasts more than 12 hours. It is distributed in all tissues, accumulates in the liver and lungs. It is excreted by the intestine (60% of the administered dose) and by the kidneys (40%), mainly in the form of metabolites.

Indications of the drug Trexyl

Seasonal allergic rhinitis, allergic skin lesions with pruritus and erythema (urticaria, dermographism, atopic eczema, contact dermatitis), atopic asthma and asthma caused by physical exertion, acute allergic reactions to drugs, food, insect bites, etc .; colds.

Contraindications

Hypersensitivity.

Application in pregnancy and breastfeeding

It should not be taken during lactation; At pregnancy it is recommended only in those cases when results of therapeutic action justify risk for a fetus.

Side effects

Dyspeptic disorders, dryness of the mucous membranes of the mouth, nose, pharynx, cough, sore throat, epistaxis, increased transaminase levels, skin reactions (alopecia, angioedema, photosensitization, rash), extrasystole (in patients with impaired liver function).

Interaction

Does not affect the depressive effects of alcohol and benzodiazepines, enhances the effect of corticosteroids and sodium cromoglycate, is compatible with bronchodilators and H2-receptor antagonists.

Dosing and Administration

Inside. Adults and children over 12 years: 60 mg 2 times / day.

Children under 12 years: 1/2 table. 2 times / day.

Overdose

It is recommended to remove the non-sucked drug, cardiomonitoring for at least 24 h (there may be an extrasystole), symptomatic and supportive therapy.

Storage conditions of the drug Trexyl

In a dry, cool place protected from light.

Keep out of the reach of children.

Shelf life of the drug Trexyl

3 years.

Do not use after the expiry date printed on the package.

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