DR. DOPING

Instructions

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Instructions / Instruction for use: Tamoxen

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Active substance Tamoxifen

ATX code L02BA01 Tamoxifen

Pharmacological groups

Estrogens, gestagens; Their homologues and antagonists

Antineoplastic hormonal agents and hormone antagonists

Nosological classification (ICD-10)

C50 Malignant neoplasm of breast

Cancer of the nipple and areola of the breast, Breast carcinoma, The hormone-dependent form of recurrent breast cancer in women in menopause, Hormone-dependent breast cancer, Disseminated breast carcinoma, Disseminated Breast Cancer, Malignant breast cancer, Malignant neoplasm of breast, Contralateral breast cancer, Locally advanced or metastatic breast cancer,Locally-distributed breast cancer, Locally-recurring breast cancer, Metastatic breast carcinoma, Metastasis of breast tumors, Metastatic breast carcinoma, Inoperable breast carcinoma, Incompatible breast cancer, Breast cancer in women with metastases, Breast cancer in men with metastases, Breast Cancer, Breast cancer in men, Mammary cancer, Breast cancer with distant metastases, Breast cancer in postmenopausal women, Breast cancer hormone-dependent, Breast cancer with local metastases, Breast cancer with metastases, Breast cancer with regional metastases,Breast cancer with metastases, Common hormone-dependent forms of breast cancer, Common Breast Cancer, Recurrent Breast Cancer, Recurrence of breast tumors, Breast cancer, Estrogen-dependent breast cancer, Estrogen-Dependent Breast Cancer, Disseminated breast cancer with overexpression of HER2, Tumors of the mammary glands

Composition and form of release

1 tablet contains tamoxifen citrate 10 or 20 mg; In the package of 30, 60 and 100 pcs.

pharmachologic effect

Pharmacological action - antitumor, antiestrogenic.

Indications

Breast cancer (mainly in the postmenopausal period).

Contraindications

Hypersensitivity, pregnancy.

pregnancy and lactation

Contraindicated in pregnancy. During treatment, reliable contraception should be provided.

Side effects

Loss of appetite, nausea, vomiting, hot flashes, dizziness, headache, depression; Peripheral edema, thrombocytopenia, leukopenia, anemia, rarely - hypercalcemia. In patients receiving exceptionally high doses for a long time, ophthalmic reactions may occur (decreased visual acuity, corneal opacity, retinopathy).

Interaction

Increases the hepatotoxicity of allopurinol, the effect of coumarin derivatives.

Dosing and Administration

Inside, 10-20 mg 2 times a day.

Precautionary measures

It is necessary to control the calcium content in the blood (especially when metastasizing in the bone). High level (hypercalcemia) requires discontinuation of treatment. With caution appoint patients with leukopenia or thrombocytopenia (it is necessary to periodically perform a complete blood test).

storage conditions

In the dark place.

Keep out of the reach of children.

Shelf life of Tamoxen

4,5 years.

Do not use after the expiry date printed on the package.

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