DR. DOPING

Instructions

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Instructions / Instruction for use: Solu-Medrol

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Active substance Methylprednisolone

ATX Code H02AB04 Methylprednisolone

Pharmacological group

Glucocorticosteroids

Composition and form of release

Lyophilizate for solution for injection 1 fl.

Methylprednisolone (as sodium succinate) 500 or 1000 mg

Auxiliary substances: monobasic monobasic sodium phosphate; Sodium dihydrogen phosphate

Solvent: benzyl alcohol - 9 mg; Water for injection - q.s. 1 ml

In a pack of cardboard 1 bottle complete with a solvent in vials.

Lyophilizate for solution for injection 1 fl

Methylprednisolone (as sodium succinate) 40 mg

Excipients: lactose; Monohydrate monobasic sodium phosphate; Sodium dihydrogen phosphate

In a pack of cardboard 1 vial of two-action Act-0-Vial.

Lyophilizate for solution for injection 1 fl

Methylprednisolone (as sodium succinate) 125 or 250 mg

Auxiliary substances: monobasic monobasic sodium phosphate; Sodium dihydrogen phosphate

In a pack of cardboard 1 vial of two-action Act-0-Vial.

pharmachologic effect

Pharmacological action - glucocorticoid.

Dosing and Administration

In / in, / m or in the form of IV infusion, but with urgent conditions, treatment is started with IV injection. Children should be given lower doses (but not less than 0.5 mg / kg / day), but when choosing a dose, first of all, the severity of the condition and the patient's reaction to therapy, rather than age and body weight, are taken into account.

As an additional therapy for life-threatening conditions - in / in, 30 mg / kg for at least 30 minutes. The introduction can be repeated every 4-6 hours for no more than 48 hours.

Pulse therapy in the treatment of diseases in which corticosteroid therapy is effective, with exacerbations of the disease and / or with ineffectiveness of standard therapy.

Ncological diseases in the terminal stage - to improve the quality of life - in / in 125 mg / day daily for up to 8 weeks.

Prevention of nausea and vomiting associated with chemotherapy for cancer. In chemotherapy, characterized by a slight or moderate vomiting effect, intravenously 250 mg for at least 5 minutes 1 hour prior to the administration of chemotherapy, at the beginning and after the end of the injection. To enhance the effect with the first dose of the drug Solu-Medrol, it is possible to administer preparations of chlorophenotiazine.

In chemotherapy characterized by severe emetic action, intravenously 250 mg for at least 5 minutes in combination with appropriate doses of metoclopramide or butyrofenone 1 hour prior to chemotherapy, then IV 250 mg at the beginning and after the end of the injection.

Acute traumatic spinal cord injuries. Treatment should be started within the first 8 hours after the injury. An intravenous bolus dose of 30 mg / kg is recommended for 15 minutes, then a continuous infusion of 5.4 mg / kg / h for 23 hours is performed after a 45-minute interval. The drug should be injected with an infusion pump into an isolated Vein.

With other indications, the initial dose is 10-500 mg IV depending on the nature of the disease. For a short course in severe acute conditions, higher doses may be required. The initial dose, not exceeding 250 mg, should be administered IV for at least 5 minutes, a dose of more than 250 mg - at least 30 minutes. Subsequent doses are administered iv or I / m, and the duration of the intervals between administrations depends on the patient's response to therapy and on his clinical condition.

Preparation of solutions.

Preparations for parenteral administration should, if possible, be checked visually for changes in color or appearance of particles.

A) Two-vial bottle Act-0-Vial:

1. Press on the plastic activator to allow the solvent to pour into the lower container.

2. Gently shake the bottle until the powder dissolves.

3. Remove the plastic disc covering the center of the plug.

4. Treat the surface of the plug with a suitable antiseptic.

5. Pierce the center of the cork with the needle so that the tip of the needle is visible. Flip the bottle and take the necessary amount of the solution with a syringe.

B) Bottle.

With the observance of aseptic enter the solvent into the vial with lyophilizate. Use only a special solvent.

C) Preparation of solutions for intravenous infusion.

Prepare the solution as above. The preparation can also be administered as diluted solutions obtained by mixing the stock solution of the preparation with a 5% aqueous solution of dextrose, with saline solution, with a 5% dextrose solution in 0.45% or 0.9% sodium chloride solution. The prepared solutions are physically and chemically stable for 48 hours.

Storage conditions

At a temperature of 20-25 ° C.

Keep out of the reach of children.

Shelf life

5 years. The solution is suitable for use within 48 hours after preparation.

Do not use after the expiry date printed on the package.

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