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Instruction for use: Remestyp

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ATX Code H01BA04 Terlipressin

Active substance: Terlipressin

Pharmacological group

Hormones of the hypothalamus, pituitary gland, gonadotropins and their antagonists

Uterotonics

Nosological classification (ICD-10)

I85.0 Varicose veins of the esophagus with bleeding

Bleeding from the esophagus, Bleeding from esophageal varices

K92.2 Gastro-intestinal bleeding, unspecified

Gastric and intestinal bleeding, Acute bleeding from the upper gastrointestinal tract, gastrorrhagia, Gastrointestinal bleeding, Intraoperative abdominal bleeding, enterorrhagia, Bleeding in the upper digestive tract, Gastrointestinal bleeding, Bleeding from the upper gastrointestinal tract, Bleeding from the gastrointestinal tract, Intraoperative bleeding abdominal, Recurrent bleeding in the digestive tract, Diagnosis of bleeding from the small intestine, peptic ulcer bleeding, Mallory-Weiss syndrome, Recurrent bleeding from peptic ulcers, Bleeding stomach

N93 Other abnormal bleeding from the uterus and vagina

Atonic uterine bleeding, Prolonged menstruation, Blood loss during menstruation, Bleeding from the genitourinary system, Bleeding uterine dysfunctional, Bleeding from the genital tract of organic etiology, Uterine bleeding, Menorrhagia with fibroids, Functional uterine bleeding, Abnormal bleeding from the genitals in women

R58 Bleeding, not elsewhere classified

Abdominal apoplexy, Hemorrhagia, Haemorrhage of the esophagus, Hemorrhage, Generalized bleeding, Diffuse bleeding, Diffuse bleeding, Prolonged bleeding, Blood loss, Blood loss during surgical interventions, Bleeding during surgery and in the postoperative period, Bleeding during labor, Bleeding and haemorrhage in hemophilia B, Bleeding from the gums, Bleeding intraoperative abdominal, Bleeding against a background of coumarin anticoagulants, Hepatic hepatitis, Bleeding at hemophilia A,Bleeding with inhibitory forms of hemophilia A and B, Bleeding due to leukemia, Bleeding in patients with leukemia,Bleeding,Bleeding due to portal hypertension, Bleeding due to hyperfibrinolysis, Drug bleeding, Local bleeding, Local bleeding due to activation of fibrinolysis, Massive blood loss, Acute blood loss, Parenchymal hemorrhage, Hepatic bleeding, Postoperative hemorrhage, Kidney bleeding,Vascular-platelet hemostasis, Traumatic bleeding, Threatening bleeding, Chronic blood loss

T81.0 Bleeding and hematoma complicating the procedure, not elsewhere classified

Bleeding in the postoperative period, Bleeding during transfusion, Bleeding during operations on the brain, Bleeding during surgical interventions, Bleeding after colorectal interventions, Bleeding after prostatectomy, Bleeding during surgery and in the postoperative period, Bleeding due to surgery on the prostate and urinary tract

Z100 * CLASS XXII Surgical practice

Abdominal surgery, adenomectomy, Amputation, Coronary angioplasty, Angioplasty of the carotid arteries, Antiseptic skin treatment for wounds, Antiseptic Hand, Appendectomy, atherectomy, Balloon coronary angioplasty, Vaginal hysterectomy, The coronary bypass, Interventions in the vagina and cervix, Interventions on the bladder, Intervention in the mouth, Restoration and reconstructive surgery, Hand hygiene of medical personnel, Gynecologic surgery, Gynecological intervention, Gynecological surgery, Hypovolemic shock during operations, Disinfection of purulent wounds, Disinfection of wounds edges, Diagnostic intervention, Diagnostic procedures, Cervical Diathermocoagulation, Long-surgery, Replacing the fistula catheters, Infection in orthopedic surgery, Artificial heart valve, cystectomy, Short-term outpatient surgery, Short-term operation, Short surgical procedures, Krikotireotomiya, Blood loss during surgery, Bleeding during surgery and in the postoperative period, Kuldotsentez, laser photocoagulation, laser coagulation, retinal laser coagulation, Laparoscopy, Laparoscopy in Gynecology, CSF fistula, Small gynecological operations, Small surgical procedures, Mastectomy and subsequent plastic, mediastinotomy, Microsurgical operations on the ear, Mukogingivalnye operation, suturing, Minor surgery, neurosurgical operation, Immobilization of the eyeball in ophthalmic surgery, testectomy, pancreatectomy, Perikardektomiya, The period of rehabilitation after surgery, The period of, convalescence after surgery, Percutaneous transluminal coronary angioplasty, Pleural thoracentesis, Pneumonia postoperative and posttraumatic, Preparation for surgical procedures, Preparation for surgery, Preparation of the surgeon's hands before surgery, Preparation of the colon for surgical procedures, Postoperative aspiration pneumonia in neurosurgical and thoracic surgery, Postoperative nausea, Postoperative bleeding, postoperative granuloma, postoperative shock, The early postoperative period, myocardial revascularization, Radiectomy, gastric Resection, bowel resection, uterine Resection, liver Resection, enterectomy, Resection of part of the stomach, Reocclusion of the operated vessel, Bonding tissues during surgical procedures, Removal of sutures, Condition after eye surgery, Condition after surgery, Condition after surgery in the nasal cavity, Condition after gastrectomy, Status after resection of the small intestine, Condition after tonsillectomy, Condition after removal of the duodenum, Condition after phlebectomy, Vascular surgery, Splenectomy, Sterilization of surgical instruments, Sterilization of surgical instruments, sternotomy, Dental surgery, Dental intervention in periodontal tissues, strumectomy, Tonsillectomy, Thoracic surgery, total gastrectomy, Transdermal intravascular coronary angioplasty, Transurethral resection, Turbinektomiya, Removal of a tooth, cataract surgery, Removal of cysts, tonsillectomy, Removal of fibroids, Removing the mobile primary teeth, Removing polyps, Removing broken tooth, Removal of the uterus body, Removal of sutures, Urethrotomy, Fistula likvoroprovodyaschih ways, Frontoetmoidogaymorotomiya, Surgical infection, Surgical treatment of chronic limb ulcersm, Surgery, The surgery in the anal area, The surgery on the colon, Surgical practice, The surgical procedure, Surgical interventions, Surgery on the gastrointestinal tract, Surgical procedures on the urinary tract, Surgical procedures on the urinary system, Surgical intervention of the genitourinary system, Surgical procedures on the heart, Surgical manipulation, surgery, Surgery on the veins, Surgical intervention, Vascular surgery, Surgical treatment of thrombosis, cholecystectomy, Partial gastric resection, transabdominal hysterectomy, Percutaneous transluminal coronary angioplasty, Percutaneous transluminal angioplasty, Coronary artery bypass, tooth Extirpation, Extirpation of milk teeth, pulpectomy, pulsative cardiopulmonary bypass, tooth Extraction, teeth Extraction, cataract extraction, Electrocoagulation, endourological intervention, episiotomy, Etmoidotomiya, Complications after tooth extraction

Composition and form of release

Solution for injection 1 ml

Terlipressin 100 μg

Auxiliary substances: sodium chloride; acetic acid; Sodium acetate trihydrate; water for injections

In ampoules of 2, 5 and 10 ml; In the box there are 5 ampoules.

pharmachologic effect

Pharmacological action - hemostatic, vasopressor.

Like the endogenous hormone vasopressin increases the tone of the smooth muscles of the vascular wall, causes narrowing of arterioles, veins and venules of visceral organs, which leads to a decrease in portal pressure. Terlipressin causes an increase in tone and an increase in the peristalsis of the intestinal tube, stimulates contraction of the myometrium.

Pharmacodynamics

Reduces blood flow in the smooth muscle organs, the liver and lowers the pressure in the portal system. It causes a reduction in smooth muscles of the esophagus, increased tone and increased intestinal motility, an increase in the tone of the smooth muscles of the uterus, stimulating the activity of the myometrium in both the pregnant and not pregnant uterus. Does not have antidiuretic effect.

Indications

Bleeding from the gastrointestinal tract (including varicose veins of the esophagus), genitourinary system, intraoperative abdominal bleeding.

Contraindications

Early pregnancy, toxicosis of pregnant women, epilepsy.

Side effects

Pallor, increased intestinal peristalsis (abdominal pain, belching, nausea, vomiting), uterine contractions (pain).

Interaction

Strengthens the effect of oxytocin and methylergometrine.

Dosing and Administration

Bleeding from varicose veins of the esophagus: 1.0 mg (1000 μg) with an interval of 4-6 hours, until the bleeding stops.

Bleeding from the gastrointestinal tract of another localization: intravenously or drip 1.0 mg (1000 μg) at intervals of 4-6 hours (the drug can be used in the provision of first aid for suspected bleeding from the gastrointestinal tract).

Bleeding from the organs of the genitourinary system: in / in jet or drip 0.2-1.0 mg (200-1000 μg) every 4-6 hours, with juvenile metrorrhagia - 5-20 μg / kg. Preferably, I / in (especially large doses), in exceptional cases - in / m.

When gynecological operations (local administration): to 0.4 mg of the drug, add salt solution, bring the volume to 10 ml, enter the cervix or paracervical. The effect occurs after 5-10 minutes. If necessary, repeated administration in an increased dose.

Precautionary measures

With caution appoint with IHD, arterial hypertension, arrhythmia, bronchial asthma.

storage Conditions

In the dark place at a temperature of 2-8 ° C. At room temperature - no more than 1 month.

Keep out of the reach of children.

Shelf life

2 years.

Do not use after the expiry date printed on the package.

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