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Instruction for use: Picamilon

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Trade name of the drug – Picamilon

International nonproprietary name: nicotinoyl gamma-aminobutyric acid
Dosage Form: pills
Composition:
Active ingredient - sodium nicotinoyl gamma-aminobutyrate - 20 mg or 50 mg,
Excipients - potato starch, magnesium hydroxycarbonate, sugar, calcium stearate, talc.
Description:
Tablets of white color.

Pharmacotherapeutic group: nootropic agent.

ATX Code [N06BX].

Pharmacological Properties
Pharmacodynamics.
Nootropic agent enhances brain vessels. It has also anxiolytic, psychostimulant, antiplatelet and antioxidant effects. It improves the functional state of the brain due to the normalization of tissue metabolism and effects on cerebral blood flow (increases the volume and the linear velocity of cerebral blood flow, reduces cerebral vascular resistance, inhibits platelet aggregation, improves microcirculation).In exchange reception improves physical and mental performance, reduces headaches, improves memory, normalizes sleep; helping to reduce or disappearance of feelings of anxiety, stress, fear; It improves the condition of patients with movement and speech disorders, reduces the inhibitory effect of ethanol on the central nervous system. It improves blood circulation in the vessels of the retina and optic nerve.
Pharmacokinetics.
Absorption - rapid and complete. It penetrates the blood-brain barrier is held long in body tissues. Bioavailability - 50-88%. Displayed mostly kidneys unchanged. The half - 0.51 hours.

Indications
Combined therapy of ischemic cerebrovascular events mild to moderate, chronic cerebrovascular insufficiency, post-traumatic brain injury, the treatment of chronic alcoholism (to reduce asthenia, asthenic-neurotic. Post-psychotic, recurrent pre-conditions, as well as alcoholic encephalopathy).In the combined therapy for migraine prophylaxis. In the complex treatment of primary open-angle glaucoma with compensated pressure, diseases of the retina and optic nerve vascular origin. In urological practice (in children older than 3 years of age and in adults with urinary disorders) to increase the adaptive function of the bladder (detrusor hypoxia reduction).In the treatment of vegetative dystonia syndrome, accompanied by anxiety, fear, increased irritability, emotional lability.

Contraindications
Hypersensitivity, chronic renal failure, pregnancy and lactation, children under 3 years.
Dosing and Administration
Inside, regardless of meals. In cerebrovascular diseases single dose - 0.02-0.05 g 2-3 times a day, the daily dose of 0.06-0.15 course of treatment - 1-2 months. A second course - after 5-6 months. For the prevention of migraine attacks of 0.05 g 3 times a day for relief of an attack -0.1 g once.Depressions late age - 0.04-0.2 g / day for 2-3 hours, the optimum dosage - 0.06-0.12 g / day, for 1.5-3 months.
As anti-astenic and anxiolytic - by 0.04-0.08 g / day. if necessary - to 0,2-0.3 g / day for 1-1.5 months.When alcoholism during abstinence - 0.1 -0.2 g / day, a short course of 6-7 days; with more persistent violations outside of abstinence - a daily dose of 0.04-0.06 g for 4-5 weeks.
To restore functionality, and at high loads - 0.06-0.08 g / day for 1-1.5 months for athletes in the same dose for 2 weeks training period.
In primary glaucoma - 0.05 grams 3 times per day for 1 month. In diseases of the retina and optic nerve Picamilon first 12 days is administered intramuscularly, and then inside of 0.02-0.05 g three times a day in a daily dose 0,06-0,015 g for 1 month.When urinary disorders: 0.02 g 2-3 times a day (for children from 3 to 10 years); 0.05 g 2 times a day (for children from 11 to 15 years), 0.05 g 3 times a day (for patients older than 15 years). The course of treatment 1 month.

Side effect
Allergic reactions (skin rash, itching), dizziness, headache, mild nausea. irritability, anxiety, excitement.

Overdose
Increased severity of symptoms of side effects. Treatment is symptomatic.

Interaction with other medicinal products.
Shortens the duration of barbiturates, enhances the effect of opioid analgesics.

Release FormTablets of 20 mg or 50 mg. 30 tablets per polymer jar. Bank with instructions for use in a pile of cardboard.
Shelf life
3 years. Do not use after the date printed on the packaging.

Storage conditions
List B in a dry, dark place, out of reach of children, at a temperature no higher than 25 °

Conditions of supply of pharmacies
on prescription

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