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Instructions

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Instruction for use: Novolid

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Active substance Nimesulide

ATX code M01AX17 Nimesulide

Pharmacological group

Other non-narcotic analgesics, including non-steroidal and other anti-inflammatory drugs

Nosological classification (ICD-10)

I80 Phlebitis and thrombophlebitis

Diseases of peripheral vessels, Inflammation of superficial veins, Inflammatory diseases of veins, Deep venous thrombophlebitis, The disease of veins, Disease of the veins of the lower extremities, Diseases of peripheral vessels, Migrating phlebitis, Insufficiency of veins of lower extremities, Exacerbation of chronic thrombophlebitis, Acute thrombophlebitis,Acute thrombophlebitis of superficial veins, Periphlebitis, Periflebit surface, Superficial inflammation of veins, Surface thrombophlebitis, Surface phlebitis, Thrombophlebitis, Deep vein thrombophlebitis, Thrombophlebitis superficial, Phlebitis, Phlebitis of deep veins, Phlebitis of superficial veins, Phlebopathy, Chronic thrombophlebitis, Endophlebitis

K08.8.0 * Painful toothache

Dentinal pain, Dentinal pains, Pain pulpitis, Anesthesia in dentistry, Pain syndromes in dental practice, Pain after removal of tartar, Pain when extracting a tooth, Toothache, Pain after dental interventions

M06.9 Other specified rheumatoid arthritis

Rheumatoid arthritis,Pain syndrome in rheumatic diseases, Pain in rheumatoid arthritis, Inflammation in rheumatoid arthritis, Degenerative forms of rheumatoid arthritis, Children's rheumatoid arthritis, Exacerbation of rheumatoid arthritis, Acute articular rheumatism, Rheumatic arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatoid arthritis of active course, Rheumatoid arthritis, Rheumatoid polyarthritis, Acute rheumatoid arthritis, Acute rheumatism

M10 Gout

Exacerbation of gout, Acute articular attack with gout, Acute gouty attack, Gouty attack, Recurrent gout attacks, Chronic gout

M13.9 Arthritis, unspecified

Arthritis,Purulent arthritis (non-infectious), acute Arthritis,Pain in acute inflammatory diseases of the musculoskeletal system,Pain in chronic inflammatory diseases of the musculoskeletal system,The pain in osteoarthritis, Inflammation in osteoarthritis, Inflammatory arthropathy, Inflammatory and degenerative joint diseases, Inflammatory disease of the musculoskeletal system, Inflammatory joint disease, Inflammatory diseases of the musculoskeletal system, destructive arthritis, The disease of the musculoskeletal system, Diseases of the musculoskeletal system, Diseases of the musculoskeletal system and connective tissue, Infections musculoskeletal system, monoartrit, Non-infectious arthritis, rheumatic arthritis, Osteoarthritis, Acute inflammation of the musculoskeletal tissue, Acute inflammatory diseases of the musculoskeletal system, Acute inflammatory condition of the musculoskeletal system, Acute arthritis, Acute osteoarthritis, Post-traumatic osteoarthritis, Reactive arthritis, Chronic inflammatory diseases of the joints, Chronic arthritis, Chronic inflammatory arthritis, Chronic inflammation of the inner layer of the joint capsule, Chronic inflammation of the joint capsule,Chronic inflammatory disease of the joints, Exudative arthritis

M15-M19 Osteoarthritis

M45 Ankylosing spondylitis

Ankylosing spondylarthrosis, Marie-Strumpel disease, Ankylosing spondylitis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Bechterew's disease, Ankylosing spondylitis, Diseases of the spinal column, Rheumatic spondylitis, Bechterew-Marie-Strumpel disease

N94.6 Dysmenorrhea Unspecified

Pain during menstruation, Functional disorders of the menstrual cycle, Menstrual cramps, Emmeniopathy, Pain during menstruation, Painful menstrual irregularities, algomenorrhea, algomenoreya, Pain smooth muscle spasm, Pain spasm of smooth muscles (renal and biliary colic, intestinal spasms, dysmenorrhea), Pain spasm of smooth muscles of internal organs (kidney and biliary colic, intestinal spasms, dysmenorrhea), Disalgomenoreya, dysmenorrhea, Dysmenorrhea (essential) (Exfoliative), menstrual disorder, menstruation painful, metrorrhagia, Violation of the menstrual cycle, Menstrual irregularities, Prolaktinzavisimoe menstrual disorders, Prolaktinzavisimoe menstrual dysfunction, Pain spasm of smooth muscles of internal organs, Spasmodic dysmenorrhea, Primary disalgomenoreya

R52 Pain, not elsewhere classified

Pain syndrome of radicular origin, Pain syndrome of small and medium intensity of different genesis, Pain syndrome after orthopedic surgery, Pain syndrome in superficial pathological processes, Radicular pain in the background of osteochondrosis of the spine, Radicular pain syndrome, Pleural pain, Chronic pain

Composition and form of release

1 tablet contains nimesulide 100 mg; in a contour acheikova packing 10 pcs., in a box 3 packings.

pharmachologic effect

Pharmacological action - anti-inflammatory, antipyretic, analgesic.

Selectively inhibits cyclooxygenase-2, suppresses synthesis of PG and metalloproteases (prevents damage to cartilaginous tissue), formation of free radicals; oppresses the liberalization of histamine, bradykinin, etc., inhibits FAT.

Pharmacokinetics

Completely absorbed after ingestion, Cmax is achieved after 1.5-3 hours and gradually decreases within 12 hours. Binding to plasma proteins is about 95%. Metabolized to 4-hydroxynimidesulide, T1 / 2 3-4.5 hours. It is excreted in the urine (70%) and with faeces (30%).

Indications

Osteoarthritis, ankylosing spondylitis, rheumatoid arthritis, gout, bursitis, tendovaginitis, pain and inflammatory processes (including trauma, infections of the ENT organs and the respiratory tract, dental interventions, pelvic organs, dysmenorrhea, thrombophlebitis, malignant neoplasms, in the postoperative period).

Contraindications

Hypersensitivity, gastric ulcer and duodenal ulcer in the stage of exacerbation, poor liver function of moderate and severe degree, pronounced renal dysfunction (Cl creatinine less than 30 ml / min), pregnancy (especially I and III trimesters), breast-feeding.

pregnancy and lactation

Contraindicated. For the duration of treatment, breastfeeding should be discontinued.

Side effects

Heartburn, nausea, epigastric pain, dizziness, skin rash.

Interaction

Care should be taken when concomitant administration with anticoagulants. Can displace from the binding sites fenofibrate, salicylic and valproic acid, tolbutamide.

Dosing and Administration

Inside, adults, 100-200 mg 2 times a day.

storage Conditions

In a dry, cool place protected from light.

Keep out of the reach of children.

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