DR. DOPING

Instructions

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Instructions / Instruction for use: Medrol

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Active substance Methylprednisolone

ATX Code H02AB04 Methylprednisolone

Pharmacological group

Glucocorticosteroids

Composition and form of release

Tablets 1 table.

Methylprednisolone 4 mg

Excipients: calcium stearate; corn starch; lactose; Sucrose

In the blister 10 pcs .; In a pack of cardboard 1, 3 or 10 blisters or in bottles of dark glass for 30 pcs .; In a pack of cardboard 1 bottle.

Tablets 1 table.

Methylprednisolone 16 mg

Excipients: calcium stearate; corn starch; lactose; Paraffin liquid; Sucrose

In the blister 10 pcs .; In a pack of cardboard 5 blisters or in a blister pack of 14; In a pack of cardboard 1 blister; Or in bottles of dark glass for 50 pcs .; In a pack of cardboard 1 bottle.

Tablets 1 table.

Methylprednisolone 32 mg

Excipients: calcium stearate; corn starch; lactose; Paraffin liquid; Sucrose

In bottles of dark glass for 20 or 50 pcs .; In a pack of cardboard 1 bottle.

pharmachologic effect

Pharmacological action - glucocorticoid.

Dosing and Administration

Inside. The dose may vary and should be selected individually, depending on the nature of the disease and the patient's response to therapy. The initial dose is from 4 to 48 mg / day, depending on the nature of the disease. In less severe cases, lower doses are usually sufficient, although higher doses may be required for individual patients. High doses may be required for such diseases and conditions as multiple sclerosis (200 mg / day), cerebral edema (200-1000 mg / day) and organ transplantation (up to 7 mg / kg / day). If a satisfactory clinical effect is not obtained after a sufficient period of time, the drug should be withdrawn and another type of therapy prescribed to the patient.

To children, the dose is determined by the doctor taking into account the mass or surface of the body. If adrenal insufficiency is 0.18 mg / kg or 3.33 mg / m2 / day in 3 doses, with other indications - 0.42-1.67 mg / kg or 12.5-50 mg / m2 / day in 3 reception.

Cancellation of the drug after prolonged therapy is recommended to be carried out gradually. If a good effect is obtained during treatment, an individual maintenance dose should be selected by gradually decreasing the initial dose at regular intervals until the lowest dose is found to maintain the clinical effect achieved. It should be remembered that constant monitoring of the dosing regimen is necessary.

There may be situations in which a dose adjustment is required, for example, changes in the clinical state due to the onset of remission or exacerbation of the disease, the patient's individual reaction to the drug, and the impact on the patient of stressful situations not directly related to the underlying disease for which therapy is directed; In the latter case, it may be necessary to increase the dose of the drug for a certain period of time, depending on the patient's condition.

Alternative therapy.

Alternating therapy is a dosing regimen in which a doubled daily dose of glucocorticosteroids is given every other day in the morning. The goal of such therapy is to achieve the maximum clinical effect in a patient taking the drug for a long time while minimizing some undesirable effects such as suppression of the pituitary-adrenal system, glucocorticosteroid cancellation syndrome and growth retardation in children.

storage conditions

At a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life

5 years.

Do not use after the expiry date printed on the package.