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Instructions / Instruction for use: Losartan-Richter

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Dosage form: film coated tablets

Active substance: Losartanum

ATX

C09CA01 Losartan

Pharmacological group

Angiotensin II receptor antagonists (AT1 subtype)

Nosological classification (ICD-10)

E11 Non-insulin-dependent diabetes mellitus: Acetonuric diabetes; Decompensation of carbohydrate metabolism; Diabetes insulin-independent sugar; Diabetes mellitus type 2; Type 2 Diabetes; Non-insulin-dependent diabetes; Non-insulin dependent diabetes mellitus; Non-insulin-dependent diabetes mellitus; Insulin resistance; Insulin resistant diabetes mellitus; Coma lactobacillus diabetic; Violation of carbohydrate metabolism; Type 2 diabetes mellitus; Diabetes mellitus type II; Diabetes mellitus in adulthood; Diabetes mellitus in old age; Diabetes insulin-independent; Diabetes mellitus type 2; Sugar insulin-independent diabetes type II

I10 Essential (primary) hypertension: hypertension; Arterial hypertension; Arterial hypertension crisis course; Essential Hypertension; Essential hypertension; Essential hypertension; Essential hypertension; Essential hypertension; Primary hypertension; Arterial hypertension, complications of diabetes; The sudden increase in blood pressure; Hypertensive disorders of blood circulation; hypertensive condition; hypertensive crises; arterial Hypertension; malignant Hypertension; Hypertonic disease; hypertensive crises; accelerated hypertension; malignant hypertension; The aggravation of hypertensive disease; Transient hypertension; Isolated systolic hypertension

I15 Secondary hypertension: Arterial hypertension, complications of diabetes; hypertension; The sudden increase in blood pressure; Hypertensive disorders of blood circulation; hypertensive condition; hypertensive crises; hypertension; arterial Hypertension; malignant Hypertension; hypertensive crises; accelerated hypertension; malignant hypertension; The aggravation of hypertensive disease; Transient hypertension; hypertension; Arterial hypertension; Arterial hypertension crisis course; renovascular hypertension; Hypertension symptomatic; Renal hypertension; Renovascular hypertension; renovascular hypertension; Symptomatic hypertension

I50.0 Congestive heart failure: anasarca heart; Decompensated congestive heart failure; Congestive heart failure; Congestive heart failure with high afterload; Congestive chronic heart failure; Cardiomyopathy with severe chronic heart failure; Compensated chronic heart failure; Swelling with circulatory failure; Edema of cardiac origin; Swelling of the heart; Edematous syndrome in diseases of the heart; Edematous syndrome in congestive heart failure; Edematous syndrome in heart failure; Edematous syndrome in heart failure or liver cirrhosis; right ventricular failure; Congestive Heart Failure; Heart failure stagnant; Heart failure with low cardiac output; Heart failure is a chronic; Cardiac edema; Chronic decompensated heart failure; Chronic Congestive Heart Failure; Chronic heart failure; Change of liver function in heart failure

N08.3 Glomerular lesions in diabetes mellitus (E10-14 + with common fourth sign .2): Nephropathy diabetic; Diabetic Nephropathy; Diabetic nephropathy in the background of type 1 diabetes mellitus; Diabetic nephropathy in patients with type I diabetes; Proteinuria in patients with type 2 diabetes mellitus

Composition

Tablets covered with a film coating.

active substance: Losartan potassium 50 mg; 100 mg

Auxiliary substances: silicon colloidal dioxide - 0,75 / 1,5 mg; Magnesium stearate - 1,5 / 3 mg; Croscarmellose sodium - 3/6 mg; Pregelatinized starch - 20.2 / 40.4 mg; MCC - 74.55 / 149.1 mg

Film membrane: Opadry 33G28523 white (triacetin - 0.3 / 0.6 mg, macrogol 0.4 / 0.8 mg, lactose monohydrate - 1.05 / 2.1 mg, titanium dioxide (E171 - CI77891) - 1,25 / 2,5 mg, hypromellose - 2/4 mg) - 5/10 mg

Pharmachologic effect

Mode of action - antihypertensive.

Dosing and Administration

Inside, 1 time per day, regardless of food intake.

Arterial hypertension

In most cases, the initial and maintenance dose is 50 mg once a day. The maximum antihypertensive effect is achieved after 3-6 weeks of taking the drug. If necessary, the dose of the drug can be increased to 100 mg / day (in 1-2 divided doses).

Against the background of taking large doses of diuretics, it is recommended to start Lozartan-Richter with 25 mg (1/2 tablets 50 mg) per day in one session.

Do not adjust the dose to elderly patients or patients with impaired renal function, including patients on hemodialysis.

Patients with impaired liver function should be prescribed lower doses of the drug.

Chronic heart failure (with ineffective therapy with ACE inhibitors)

The initial dose of the drug Losartan-Richter is 50 mg once a day in a single dose. In the future, hydrochlorothiazide can be added at low doses and / or the dose of Losartan-Richter can be increased to 100 mg per day.

Kidney protection in patients with type 2 diabetes mellitus with proteinuria

The initial dose of the drug Losartan-Richter is 50 mg once a day in a single dose. In the course of treatment, depending on blood pressure, you can increase the daily dose of the drug to 100 mg in 1-2 divided doses.

Chronic heart failure

For the treatment of chronic heart failure, the initial dose of the drug is 12.5 mg (you can use losartan in another dosage form - tablets of 12.5 mg) at one time.

In order to reach the usual maintenance dose of 50 mg / day, the dose of Lozartan-Richter should be increased gradually, at intervals of 1 week (for example, 12.5, 25, 50 mg with a single dose per day). Losartan-Richter is usually prescribed in combination with diuretics and cardiac glycosides.

The dose of the drug should be increased according to the following scheme:

- 1st week - from the 1st to the 7th day - 1 table. 12.5 mg once a day;

- 2 nd week - from the 8 th to the 14 th day - 1/2 table. 50 mg once a day;

- 3rd week - from the 15th to the 21st day - 1 table. 50 mg once a day;

- 4th week - from the 22nd to the 28th day - 1 table. 50 mg once a day.

Release form

Film-coated tablets, 50 mg and 100 mg. In the blister of PVC / PE / PVDC and aluminum foil for 10 pcs. 1 or 3 blisters in a cardboard box.

Manufacturer

1. JSC Gedeon Richter. Hungary.

2. Grodzis Pharmaceutical Plant "Polfa" sro.

Conditions of supply of pharmacies

On prescription.

Storage conditions of the drug Losartan-Richter

In a dry place, at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

The shelf life of the drug Losartan-Richter

5 years.

Do not use beyond the expiration date printed on the package.


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