Instruction for use: Dexamethasone phosphate

Active substance: Dexamethasone

ATX Code H02AB02Dexamethasone

Pharmacological group

Glucocorticosteroids

The nosological classification (ICD-10)

A41.9 Septicemia, unspecified

Septic diseases, Septicemia / bacteremia, Toxico-infectious shock, Endotoxin shock, Bacterial septicemia, Bacterial infections of severe course, Generalized infections, Generalized systemic infections, Infections generalized, Wound sepsis, Septiccopymia, Septic-toxic complications, Septicemia, Septic conditions, Septic shock, Septic condition, Septic shock

B99 Other infectious diseases

Infections (opportunistic), Infections on the background of immunodeficiency, Opportunistic infections

C81 Hodgkin's disease [lymphogranulomatosis]

Paltauf-Sternberg disease, The generalized form of Hodgkin's disease, Lymphogranulomatosis, Hodgkin's disease, Hodgkin's lymphoma, Hodgkin's malignant lymphoma, Hodgkin's lymphoma, Lymphoproliferative diseases, Reticulosis fibromyaloid, Pelya-Ebstein fever

D55-D59 Hemolytic anemia

D69.6 Thrombocytopenia, unspecified

Hemorrhagic diathesis of thrombocytopenic origin, Hemorrhagic syndrome of thrombocytopenic origin, Idiopathic thrombocythemia, Thrombocytopenia, May-Hegglina anomalies, Hereditary thrombocytopathies, Fever with thrombocytopenia

D70 Agranulocytosis

Agranulocytosis is hereditary, Aleicia, Aleykocytosis, Agranulocytic angina, Angina agranulocytic, Primary cytopenia

E27.4 Other and unspecified adrenocortical insufficiency

Hypocorticism, Hypoaldosteronism, Adrenal insufficiency, Insufficiency of the adrenal cortex, Insufficiency of the adrenal cortex, Secondary adrenocortical insufficiency, Secondary adrenal insufficiency, Secondary insufficiency of the adrenal cortex, Temporary decrease in the function of the adrenal cortex, Dysfunction of the adrenal cortex

G93.6 Edema of the brain

Intraoperative cerebral edema, Cerebral edema, Post-traumatic swelling of the brain, Brain edema associated with radiation therapy, Brain edema associated with head trauma, Post-traumatic cerebral edema, Edema of the brain in poisoning

J46 Status asthmaticus

Asthmatic attack, status asthmaticus, Bronchospasm in bronchial asthma

J98.8.0 * Bronchospasm

Bronchospasm in bronchial asthma, Bronchospasm when exposed to an allergen, bronchospastic reactions, bronchospastic status, bronhospastichesky syndrome, Diseases accompanied by bronchospastic syndrome, reversible bronchospasm, spasmodic cough

M00-M25 Arthropathy

M05 Seropositive rheumatoid arthritis

Rheumatoid arthritis seropositive

M10 Gout

Exacerbation of gout, Acute articular attack with gout, Acute gouty attack, Gouty attack, Recurrent gout attacks, Chronic gout

M15-M19 Osteoarthritis

M30-M36 Systemic involvement of connective tissue

Collagenoses

M71 Other bursopathies

Bursitis, Bursopathy, Diseases of soft tissues, Osteoarthritis in musculo-articular diseases, Inflammatory disease of soft tissues, Subacute bursitis

M77.9 Other unspecified

Capsule, Periarthritis, Tendonitis, Tendopathy, Periarthropathy

M79.0 Other unspecified rheumatism

Degenerative rheumatic disease, Degenerative and rheumatic diseases of the tendons, Degenerative rheumatic diseases, Localized forms of rheumatism of soft tissues, Rheumatism, Rheumatism with a pronounced allergic component, Rheumatism of the articular and extraarticular, Rheumatic attack, Rheumatic complaints, Rheumatic diseases, Rheumatic disease of the spine, Relapses of rheumatism, Articular and extra-articular rheumatism, Articular and muscular rheumatism, Articular rheumatism, Articular syndrome with rheumatism, Chronic rheumatic pain, Chronic articular rheumatism, Rheumatoid diseases, Rheumatic diseases of the intervertebral disc

R57 Shock, not elsewhere classified

Obstructive shock

R57.0 Cardiogenic shock

cardiogenic shock

T78.2 Anaphylactic shock, unspecified

Anaphylactic shock, Anaphylactoid reaction, Anaphylactic shock, Anaphylactic reactions, Anaphylactic shock to drugs

T78.3 Angioedema

Edema Quincke, Laryngeal exacerbation with angioneurotic edema, Recurrent angioedema, Allergic edema, Recurrent swelling of Quincy

T78.4 Allergy, unspecified

Allergic reactions to insulin, Allergic reactions to insect stings, Allergic reactions similar to systemic lupus erythematosus, Allergic diseases, Allergic diseases of mucous membranes, Allergic diseases and conditions resulting from increased release of histamine, Allergic diseases of mucous membranes, Allergic symptoms, Allergic symptoms in the mucous membranes, Allergic reactions, Allergic reactions caused by insect bites, Allergic reactions, Allergic conditions, Allergic laryngeal edema, allergopathy, allergic conditions, Allergy, House dust allergy, Anaphylaxis, Cutaneous reactions to medications, Skin reaction to insect stings, Cosmetic allergy, Drug allergy, Acute allergic reaction, Laryngeal edema allergic genesis and background radiation, Food and drug allergy

T79.4 Traumatic shock

Hemorrhagic shock, Crush syndrome, hemorrhagic shock, postoperative shock, post-traumatic shock, traumatic shock, hemorrhagic shock and encephalopathy syndrome

T81.1 Shock during or after the procedure, not elsewhere classified

Operating shock, Postoperative shock, Operational shock

Composition and form of release

1 ampoule with 1 ml solution for injection contains dexamethasone phosphate (in the form of disodium salt 21-dihydrogen phosphate) 4 mg; In the box 10 pcs.

pharmachologic effect

Pharmacological action - anti-inflammatory, antiallergic, immunosuppressive, anti-shock, desensitizing.

Inhibits the metabolism of arachidonic acid, inhibits the biosynthesis of PG (prostaglandins), leukotrienes and other mediators of inflammation and allergies.

Indications

Shock of different genesis, cerebral edema, asthmatic status, severe allergic reactions (Quincke's edema, bronchospasm, anaphylactic reactions to medications, etc.); Rheumatism, collagenoses, arthritis, degenerative diseases of joints, inflammatory diseases of joints (bursitis, tendovaginitis, periarthritis, polyarthritis, arthrosis, etc.); Acute hemolytic anemia, thrombocytopenia, lymphogranulomatosis, agranulocytosis, severe infectious diseases (in combination with antibiotics), acute adrenal insufficiency (in combination with mineralocorticoids).

Contraindications

Peptic ulcers of the digestive tract (gastrointestinal tract), severe osteoporosis, psychosis, viral diseases, purulent eye diseases, active form of tuberculosis, amoebic infections, systemic mycoses, cerebral palsy, glaucoma, up to (8 weeks) and after (2 weeks) Preventive vaccinations.

Side effects

With short-term therapy (up to 10 days) - gastrointestinal bleeding, reduced immunity, a decrease in glucose tolerance. With prolonged therapy - Syndrome Itenko-Cushing. At the injection site - aseptic necrosis of the bone (in the region of the femur, head of the humerus), abscesses, infection, tenderness. Allergic reactions, redness of the face.

Dosing and Administration

In / in (intravenously), in / m (intramuscularly), intra- and periarticularly. Doses are set individually, depending on the type and severity of the disease and on the sensitivity of the patient. Recommended doses: for IV (intravenous) and IM (intramuscular) administration for the treatment of systemic diseases - 0.2-20 mg; For the treatment of affected joints (periarticular or intra-articular injection) - 2-8 mg.

Precautionary measures

With caution appoint with severe arterial hypertension, diabetes, hypothyroidism, liver cirrhosis; With great care - during pregnancy (especially in the first trimester), children (during long-term treatment it is necessary to monitor the dynamics of growth and development). For the duration of treatment, lactating women should stop breastfeeding. When infectious diseases are prescribed against the background of antibiotics. To avoid the withdrawal syndrome, treatment is gradually stopped.

storage conditions

Keep out of the reach of children.